Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers
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منابع مشابه
Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers
The identification of cancer stem cells in vivo and in vitro relies on specific surface markers that should allow to sort cancer cells in phenotypically distinct subpopulations. Experiments report that sorted cancer cell populations after some time tend to express again all the original markers, leading to the hypothesis of phenotypic switching, according to which cancer cells can transform sto...
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cancer stem cells (csc) are the tumor-associated cells existed within tumors or hematological cancers which share characteristics similar to normal stem cells. the common characteristics of a normal stem cell and a csc are their differentiation capacity and self-renewal in tumors. the expression pattern of csc markers differs depending on the type and location of cancers. cd molecules are proba...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2012
ISSN: 2045-2322
DOI: 10.1038/srep00441